SELIMETRY—a multicentre I-131 dosimetry trial: a clinical perspective
نویسندگان
چکیده
منابع مشابه
SELIMETRY—a multicentre I-131 dosimetry trial: a clinical perspective
Treatment options for patients with thyroid cancer that is no longer sensitive to iodine therapy are limited. Those treatments which currently exist are associated with significant toxicity. The SELIMETRY trial (EudraCT No 2015-002269-47) aims to investigate the role of the MEK inhibitor Selumetinib in resensitizing advanced iodine refractory differentiated thyroid cancer to radioiodine therapy...
متن کاملRabbit internal dosimetry for iodine-131 using GATE Monte Carlo simulation code: a preclinical trial
Introduction: One of the main concerns in administration of radiotracers, especially in therapeutic arm, is the amount of delivered dose to the different organs. Individual variations of anatomy, physiology and underlying pathology in the patients lead to alteration of administered activity. In the current study we preclinically applied internal dosimetry using an animal mod...
متن کاملDetermination of absorbed ratio in I-131 dosimetry using MCNP-4A [Persian]
Determination of the total body absorbed dose consists of two parts: Beta radiation absorbed dose and gamma radiation absorbed dose. The first part is generally determined by clinical data, while the second part has a parameter called absorbed ratio and is determined by computational methods. The Monte-Carlo computational methods have been shown to be the most suita...
متن کاملUnited Kingdom multicentre clinical trial of somatrem.
In a multicentre clinical trial 54 children aged 4.0 to 17.3 years, who had growth hormone deficiency that had not previously been treated, were given biosynthetic methionyl growth hormone (somatrem) 4 units three times a week by subcutaneous or intramuscular injection for one year. Height was measured every three months for at least one year before and during treatment. Forty two patients resp...
متن کاملدرمان تومورهای غددی-عصبی با I-131 Metaiodobenzylguanidine (I-131 MIBG)
زمینه: کاربرد رادیودارویI-131 MIBG در درمان تومورهای با منشأ غددی- عصبی، خصوصاً از نوع نورواکتودرمال (سمپاتوآدرنال) شامل فئوکروموسیتوم، پاراگانگلیوم و نوروبلاستوم مؤثر بوده است. در سایر تومورهای غددی- عصبی (عمدتاً کارسینوئید و کارسینوم مدولاری تیروئید) نیز این درمان گاهی میتواند مؤثر واقع گردد. مواد و روشها: در این مطالعه مروری، کارآزماییهای بالینی شاهد - موردی و همچنین مطالعات باز که دارای اع...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The British Journal of Radiology
سال: 2017
ISSN: 0007-1285,1748-880X
DOI: 10.1259/bjr.20160637